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Document 0509
DOCN M9650509
TI Clinical neurophysiological comparative study on HTLV-1 associated
myelopathy/tropical spastic paraparesis.
DT 9605
AU Leon FE; Arimura K; Arimura Y; Sonoda Y; Suwazono S; Osame M; Third
Department of Internal Medicine, Kagoshima University; School of
Medicine, Japan.
SO Arch Med Res. 1995 Winter;26(4):397-403. Unique Identifier : AIDSLINE
MED/96107859
AB In order to determine the neurophysiological characteristics of
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
throughout the world, we analyzed and compared the most common clinical
neurophysiological studies (CNPS) performed in this entity from those
places with a high prevalence and interesting regional differences were
noted. African patients showed a noteworthy involvement of the
peripheral nervous system (PNS). Chilean patients displayed a more
circumscribed abnormality around the spinal cord. The migrants from the
West Indies to England showed important visual, and somatosensory evoked
potential (SSEP) alterations in the upper limbs (UL). Japanese patients
also presented some involvement of the PNS, but their illness duration
was less protracted than that observed in other countries. The
differences found in visual pathways and PNS involvement among these
groups were statistically significant (p < 0.05). Thus, this study shows
not only a widespread subclinical involvement in both central and PNS in
HAM/TSP, but also strongly supports the idea that the lesion
distribution and progression of this disease are different among
countries. Such differences could likely be due to the action of the
so-called environmental co-factors present in each of these areas which
should be promptly investigated.
DE Comparative Study Human *HTLV-I Nervous System/*PHYSIOPATHOLOGY
Paraparesis, Tropical Spastic/*PHYSIOPATHOLOGY/*VIROLOGY Support,
Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).